Tissue Engineering of Oral Mucosa and Salivary Gland: Disease Modeling and Clinical Applications

Tissue Engineering of Oral Mucosa and Salivary Gland: Disease Modeling and Clinical Applications

Blog Article

Oral mucosa and salivary gland are composed of complex and dynamic networks of extracellular matrix, multiple cell types, vasculature, and various biochemical agents.Two-dimensional (2D) cell culture is commonly used in testing new drugs and experimental therapies.However, 2D cell culture Acne cannot fully replicate the architecture, physiological, and pathological microenvironment of living human oral mucosa and salivary glands.Recent microengineering techniques offer state of the science cell culture models that can recapitulate human organ structures and functions.

This narrative review describes emerging in vitro models of oral and salivary gland tissue such as 3D cell culture models, spheroid and organoid models, INCENSE INDIAN CEDAR tissue-on-a-chip, and functional decellularized scaffolds.Clinical applications of these models are also discussed in this review.